Gas Chromatography and Mass Spectrometry in Clinical Chemistry
نویسنده
چکیده
Automated spectrophotometric, electrochemical, and immunochemical analyses have become the mainstays of clinical chemistry and toxicology laboratory services, but their scope is limited. A wide array of clinically relevant analytes demand more sophisticated analytical techniques to provide sensitive and specific assays for diagnostic purposes. Gas chromatography (GC) and mass spectrometry (MS) are becoming cost-effective alternatives for many of these challenging assays. GC is a robust technique that offers the ability to resolve volatile components of a complex mixture. MS provides structural information that can unambiguously identify a compound. In combination, these two techniques provide qualitative and quantitative answers to many difficult analytical problems. GC and MS applications have been developed for a variety of clinical analytes, and the use of these methods has created new and exciting frontiers for clinical laboratory medicine. Several clinical applications of these analytical techniques will be discussed in this chapter.
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